The ATPases of the mycobacterial type VII secretion system: Structural and mechanistic insights into secretion
نویسندگان
چکیده
منابع مشابه
General secretion signal for the mycobacterial type VII secretion pathway.
Mycobacterial pathogens use specialized type VII secretion (T7S) systems to transport crucial virulence factors across their unusual cell envelope into infected host cells. These virulence factors lack classical secretion signals and the mechanism of substrate recognition is not well understood. Here we demonstrate that the model T7S substrates PE25/PPE41, which form a heterodimer, are targeted...
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چکیده ندارد.
Mycosins of the Mycobacterial Type VII ESX Secretion System: the Glue That Holds the Party Together
Since their discovery as important determinants of virulence and growth, the type VII ESX secretion systems (ESX-1 to ESX-5) of slow-growing pathogenic mycobacteria have been the focus of intense scrutiny. Genetic studies have been instrumental in identifying the core components and substrates of these molecular secretion machines and have helped uncover the multifunctional properties of some o...
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ژورنال
عنوان ژورنال: Progress in Biophysics and Molecular Biology
سال: 2020
ISSN: 0079-6107
DOI: 10.1016/j.pbiomolbio.2019.11.008